Literature Case Studies in Drug Discovery
About this course
Once a person understands the ideas of drug efficacy, potency, pharmacokinetics, and safety, original research articles can be readily understood. The Journal of Medicinal Chemistry of the American Chemical Society regularly publishes a series of articles called Drug Annotations. These articles summaries a drug discovery program from a pharmaceutical company. The article covers everything from the indication of the drug, key pathways and promising drug targets within the pathways, library screening, lead selection, lead optimization, and both preclinical safety and PK/ADME studies. The articles are excellent articles for students who are testing their knowledge of drug discovery.
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