Lead Discovery & Optimization for Efficacy, PK, & Safety
About this course
Understanding the efficacy, potency, pharmacokinetics, and safety of compounds is important, but compounds almost always require improvement in their properties in order to become drugs. The process of improvement is called lead optimization and requires a thorough understanding of how a molecule’s structure affects its function, whether efficacy, PK, or toxicity. Unraveling a compound’s structure-function relationship enables lead optimization and hopefully results in the discovery of a compound that can be advanced into clinical trials.
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What you'll learn
- understanding the structure-function relationship of compounds
- applying concepts of lead optimization in drug development
- analyzing pharmacokinetics and safety profiles of compounds
Course objectives
- to comprehend the process of lead optimization
- to evaluate how molecular structure affects compound efficacy
- to prepare for insights into clinical trial advancements
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